Search results for " Dioxin"
showing 4 items of 4 documents
Environment and Endometriosis: A toxic relationship
2015
Endometriosis is a common, be- nign, estrogen-dependent gynecological dis- ease that represents one of the main causes of hospitalization in industrialized countries. It is well established that a large amount of natural and man-made chemicals are present in the en- vironment and both humans and animals are exposed to them. Dioxin and dioxin-like com- pounds have long biological half-life, can accu- mulate within the organism and could negative- ly affect several physiological processes. The purpose of this review is to provide an overview of the possible relationship between these chemicals and the pathogenesis of en- dometriosis.
Chloracne after release of TCDD at Seveso, Italy
1981
ABSTRACT The paper deals with clinical and epidemiological findings concerning persons showing skin lesions after release of TCDD at Seveso. A positive association was observed between geographical distribution of cases and levels of soil contamination. Gastro-intestinal tract impairments were more frequently observed in children with chloracne than in children from the same areas showing no skin lesions. To date, no major immunological involvement has been observed in samples of children exposed to TCDD.
Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems.
2017
Background 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range of toxic outcomes, ranging from chloracne to acute lethality. The severity of toxicity is highly dependent on the aryl hydrocarbon receptor (AHR). Binding of TCDD to the AHR leads to changes in transcription of numerous genes. Studies evaluating the transcriptional changes brought on by TCDD may provide valuable insight into the role of the AHR in human health and disease. We therefore compiled a collection of transcriptomic datasets that can be used to aid the scientific community in better understanding the transcriptiona…
Dioxin emissions and soft-tissue sarcoma: results of a population-based case-control study.
2004
International audience; BACKGROUND: In 1998, the French Ministry of Environment revealed that of 71 French municipal solid waste incinerators processing more than 6 metric tons of material per hour, dioxin emission from 15 of them was above the 10 ng international toxic equivalency factor/m3 (including Besançon, emitting 16.3 ng international toxic equivalency factor/m3) which is substantially higher than the 0.1 international toxic equivalency factor/m3 prescribed by a European directive of 1994. In 2000, a macrospatial epidemiological study undertaken in the administrative district of Doubs, identified two significant clusters of soft-tissue sarcoma and non Hodgkin lymphoma in the vicinit…